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coro1c d6k5b  (Cell Signaling Technology Inc)


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    Structured Review

    Cell Signaling Technology Inc coro1c d6k5b
    MiR-206 directly targets the 3′-UTR of <t>CORO1C.</t> a The sequence of human miR-206 and the predicted binding sites with miR-206 within the CORO1C 3′-UTR are shown. b MiR-206 suppresses CORO1C expression in A549 cells. The A549 cells were treated with NC mimic or miR-206 mimic for 24 h, and CORO1C expression was evaluated by western blotting assay. β-actin was used as a loading control. c MiR-206 represses CORO1C mRNA in A549 cells. The A549 cells were cotransfected with luciferase plasmids containing wild-type (WT) CORO1C 3′UTR or mutant-type (Mut) CORO1C 3′UTR. The cells were also treated with miR-206 mimic at the same time. The cells were lysed to measure the relative luciferase activity. Quantitative data are presented as mean ± SEM. ***P < 0.001 compared with the NC mimic group. d CORO1C expression in NSCLC tissues and corresponding normal mucosa tissues were detected by q-RT-PCR. e CORO1C expression in a panel of human lung cell lines and human lung epithelia BEA-2B cells was evaluated by q-RT-PCR. CORO1C expression in BEA-2B was set as 100%. Quantitative data are presented as the mean ± SEM. * **P < 0.001 compared with BEA-2B cells
    Coro1c D6k5b, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 91/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/coro1c d6k5b/product/Cell Signaling Technology Inc
    Average 91 stars, based on 2 article reviews
    coro1c d6k5b - by Bioz Stars, 2026-02
    91/100 stars

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    1) Product Images from "MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C"

    Article Title: MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

    Journal: Cellular & Molecular Biology Letters

    doi: 10.1186/s11658-020-00216-x

    MiR-206 directly targets the 3′-UTR of CORO1C. a The sequence of human miR-206 and the predicted binding sites with miR-206 within the CORO1C 3′-UTR are shown. b MiR-206 suppresses CORO1C expression in A549 cells. The A549 cells were treated with NC mimic or miR-206 mimic for 24 h, and CORO1C expression was evaluated by western blotting assay. β-actin was used as a loading control. c MiR-206 represses CORO1C mRNA in A549 cells. The A549 cells were cotransfected with luciferase plasmids containing wild-type (WT) CORO1C 3′UTR or mutant-type (Mut) CORO1C 3′UTR. The cells were also treated with miR-206 mimic at the same time. The cells were lysed to measure the relative luciferase activity. Quantitative data are presented as mean ± SEM. ***P < 0.001 compared with the NC mimic group. d CORO1C expression in NSCLC tissues and corresponding normal mucosa tissues were detected by q-RT-PCR. e CORO1C expression in a panel of human lung cell lines and human lung epithelia BEA-2B cells was evaluated by q-RT-PCR. CORO1C expression in BEA-2B was set as 100%. Quantitative data are presented as the mean ± SEM. * **P < 0.001 compared with BEA-2B cells
    Figure Legend Snippet: MiR-206 directly targets the 3′-UTR of CORO1C. a The sequence of human miR-206 and the predicted binding sites with miR-206 within the CORO1C 3′-UTR are shown. b MiR-206 suppresses CORO1C expression in A549 cells. The A549 cells were treated with NC mimic or miR-206 mimic for 24 h, and CORO1C expression was evaluated by western blotting assay. β-actin was used as a loading control. c MiR-206 represses CORO1C mRNA in A549 cells. The A549 cells were cotransfected with luciferase plasmids containing wild-type (WT) CORO1C 3′UTR or mutant-type (Mut) CORO1C 3′UTR. The cells were also treated with miR-206 mimic at the same time. The cells were lysed to measure the relative luciferase activity. Quantitative data are presented as mean ± SEM. ***P < 0.001 compared with the NC mimic group. d CORO1C expression in NSCLC tissues and corresponding normal mucosa tissues were detected by q-RT-PCR. e CORO1C expression in a panel of human lung cell lines and human lung epithelia BEA-2B cells was evaluated by q-RT-PCR. CORO1C expression in BEA-2B was set as 100%. Quantitative data are presented as the mean ± SEM. * **P < 0.001 compared with BEA-2B cells

    Techniques Used: Sequencing, Binding Assay, Expressing, Western Blot, Control, Luciferase, Mutagenesis, Activity Assay, Reverse Transcription Polymerase Chain Reaction

    CORO1C overexpression attenuates miR-206-mediated inhibitory effect on A549 cells. a CORO1C vector transfection increased CORO1C expression. The cells were treated with CORO1C vector or NC vector for 24 h, then the cells were collected for q-RT-PCR assay. b CORO1C vector transfection decreases miR-206-mediated inhibition effect on A549 cell proliferation. The cells were transfected with NC vector and CORO1C vector, and then treated with miR-206 mimic for 24 h. Then the cells were subjected to MTT assay. c and d ) CORO1C overexpression rescues miR-206-induced effect on the horizontal migration of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then applied for wound healing assay stimulated with miR-206 mimic. Representative images (100× magnification) and the quantitative data are shown in c and d , respectively. ( e and f ) CORO1C vector attenuates miR-206-mediated inhibitory effect on the vertical migration and invasion of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then subjected to transwell migration and transwell invasion assays. Representative images (100 × magnification) and the quantitative data are shown in e and f , representatively. g CORO1C vector rescues miR-206-induced inhibitory effect of EMT markers. The cells were transfected with CORO1C vector or NC vector. After 24 h the cells were collected and subjected to western blotting assay. Quantitative data are presented as mean ± SEM. *P < 0.05 and * **P < 0.001 compared with the NC vector group, # P < 0.05 and ## P < 0.01 compared with the NC vector+ NC mimic group
    Figure Legend Snippet: CORO1C overexpression attenuates miR-206-mediated inhibitory effect on A549 cells. a CORO1C vector transfection increased CORO1C expression. The cells were treated with CORO1C vector or NC vector for 24 h, then the cells were collected for q-RT-PCR assay. b CORO1C vector transfection decreases miR-206-mediated inhibition effect on A549 cell proliferation. The cells were transfected with NC vector and CORO1C vector, and then treated with miR-206 mimic for 24 h. Then the cells were subjected to MTT assay. c and d ) CORO1C overexpression rescues miR-206-induced effect on the horizontal migration of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then applied for wound healing assay stimulated with miR-206 mimic. Representative images (100× magnification) and the quantitative data are shown in c and d , respectively. ( e and f ) CORO1C vector attenuates miR-206-mediated inhibitory effect on the vertical migration and invasion of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then subjected to transwell migration and transwell invasion assays. Representative images (100 × magnification) and the quantitative data are shown in e and f , representatively. g CORO1C vector rescues miR-206-induced inhibitory effect of EMT markers. The cells were transfected with CORO1C vector or NC vector. After 24 h the cells were collected and subjected to western blotting assay. Quantitative data are presented as mean ± SEM. *P < 0.05 and * **P < 0.001 compared with the NC vector group, # P < 0.05 and ## P < 0.01 compared with the NC vector+ NC mimic group

    Techniques Used: Over Expression, Plasmid Preparation, Transfection, Expressing, Reverse Transcription Polymerase Chain Reaction, Inhibition, MTT Assay, Migration, Wound Healing Assay, Western Blot



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    coro1c d6k5b  (Cell Signaling Technology Inc)
    91
    Cell Signaling Technology Inc coro1c d6k5b
    MiR-206 directly targets the 3′-UTR of <t>CORO1C.</t> a The sequence of human miR-206 and the predicted binding sites with miR-206 within the CORO1C 3′-UTR are shown. b MiR-206 suppresses CORO1C expression in A549 cells. The A549 cells were treated with NC mimic or miR-206 mimic for 24 h, and CORO1C expression was evaluated by western blotting assay. β-actin was used as a loading control. c MiR-206 represses CORO1C mRNA in A549 cells. The A549 cells were cotransfected with luciferase plasmids containing wild-type (WT) CORO1C 3′UTR or mutant-type (Mut) CORO1C 3′UTR. The cells were also treated with miR-206 mimic at the same time. The cells were lysed to measure the relative luciferase activity. Quantitative data are presented as mean ± SEM. ***P < 0.001 compared with the NC mimic group. d CORO1C expression in NSCLC tissues and corresponding normal mucosa tissues were detected by q-RT-PCR. e CORO1C expression in a panel of human lung cell lines and human lung epithelia BEA-2B cells was evaluated by q-RT-PCR. CORO1C expression in BEA-2B was set as 100%. Quantitative data are presented as the mean ± SEM. * **P < 0.001 compared with BEA-2B cells
    Coro1c D6k5b, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/coro1c d6k5b/product/Cell Signaling Technology Inc
    Average 91 stars, based on 1 article reviews
    coro1c d6k5b - by Bioz Stars, 2026-02
    91/100 stars
    		  Buy from Supplier

    Image Search Results


    MiR-206 directly targets the 3′-UTR of CORO1C. a The sequence of human miR-206 and the predicted binding sites with miR-206 within the CORO1C 3′-UTR are shown. b MiR-206 suppresses CORO1C expression in A549 cells. The A549 cells were treated with NC mimic or miR-206 mimic for 24 h, and CORO1C expression was evaluated by western blotting assay. β-actin was used as a loading control. c MiR-206 represses CORO1C mRNA in A549 cells. The A549 cells were cotransfected with luciferase plasmids containing wild-type (WT) CORO1C 3′UTR or mutant-type (Mut) CORO1C 3′UTR. The cells were also treated with miR-206 mimic at the same time. The cells were lysed to measure the relative luciferase activity. Quantitative data are presented as mean ± SEM. ***P < 0.001 compared with the NC mimic group. d CORO1C expression in NSCLC tissues and corresponding normal mucosa tissues were detected by q-RT-PCR. e CORO1C expression in a panel of human lung cell lines and human lung epithelia BEA-2B cells was evaluated by q-RT-PCR. CORO1C expression in BEA-2B was set as 100%. Quantitative data are presented as the mean ± SEM. * **P < 0.001 compared with BEA-2B cells

    Journal: Cellular & Molecular Biology Letters

    Article Title: MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

    doi: 10.1186/s11658-020-00216-x

    Figure Lengend Snippet: MiR-206 directly targets the 3′-UTR of CORO1C. a The sequence of human miR-206 and the predicted binding sites with miR-206 within the CORO1C 3′-UTR are shown. b MiR-206 suppresses CORO1C expression in A549 cells. The A549 cells were treated with NC mimic or miR-206 mimic for 24 h, and CORO1C expression was evaluated by western blotting assay. β-actin was used as a loading control. c MiR-206 represses CORO1C mRNA in A549 cells. The A549 cells were cotransfected with luciferase plasmids containing wild-type (WT) CORO1C 3′UTR or mutant-type (Mut) CORO1C 3′UTR. The cells were also treated with miR-206 mimic at the same time. The cells were lysed to measure the relative luciferase activity. Quantitative data are presented as mean ± SEM. ***P < 0.001 compared with the NC mimic group. d CORO1C expression in NSCLC tissues and corresponding normal mucosa tissues were detected by q-RT-PCR. e CORO1C expression in a panel of human lung cell lines and human lung epithelia BEA-2B cells was evaluated by q-RT-PCR. CORO1C expression in BEA-2B was set as 100%. Quantitative data are presented as the mean ± SEM. * **P < 0.001 compared with BEA-2B cells

    Article Snippet: Antibodies against vimentin (D21H3), E-cadherin (24E10), N-cadherin (D4R1H), ZO-1(D6L1E) and Snail (C15D3), CORO1C (D6K5B) and β-actin (13E5) were purchased from Cell Signaling Technology (Danvers, MA).

    Techniques: Sequencing, Binding Assay, Expressing, Western Blot, Control, Luciferase, Mutagenesis, Activity Assay, Reverse Transcription Polymerase Chain Reaction

    CORO1C overexpression attenuates miR-206-mediated inhibitory effect on A549 cells. a CORO1C vector transfection increased CORO1C expression. The cells were treated with CORO1C vector or NC vector for 24 h, then the cells were collected for q-RT-PCR assay. b CORO1C vector transfection decreases miR-206-mediated inhibition effect on A549 cell proliferation. The cells were transfected with NC vector and CORO1C vector, and then treated with miR-206 mimic for 24 h. Then the cells were subjected to MTT assay. c and d ) CORO1C overexpression rescues miR-206-induced effect on the horizontal migration of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then applied for wound healing assay stimulated with miR-206 mimic. Representative images (100× magnification) and the quantitative data are shown in c and d , respectively. ( e and f ) CORO1C vector attenuates miR-206-mediated inhibitory effect on the vertical migration and invasion of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then subjected to transwell migration and transwell invasion assays. Representative images (100 × magnification) and the quantitative data are shown in e and f , representatively. g CORO1C vector rescues miR-206-induced inhibitory effect of EMT markers. The cells were transfected with CORO1C vector or NC vector. After 24 h the cells were collected and subjected to western blotting assay. Quantitative data are presented as mean ± SEM. *P < 0.05 and * **P < 0.001 compared with the NC vector group, # P < 0.05 and ## P < 0.01 compared with the NC vector+ NC mimic group

    Journal: Cellular & Molecular Biology Letters

    Article Title: MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C

    doi: 10.1186/s11658-020-00216-x

    Figure Lengend Snippet: CORO1C overexpression attenuates miR-206-mediated inhibitory effect on A549 cells. a CORO1C vector transfection increased CORO1C expression. The cells were treated with CORO1C vector or NC vector for 24 h, then the cells were collected for q-RT-PCR assay. b CORO1C vector transfection decreases miR-206-mediated inhibition effect on A549 cell proliferation. The cells were transfected with NC vector and CORO1C vector, and then treated with miR-206 mimic for 24 h. Then the cells were subjected to MTT assay. c and d ) CORO1C overexpression rescues miR-206-induced effect on the horizontal migration of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then applied for wound healing assay stimulated with miR-206 mimic. Representative images (100× magnification) and the quantitative data are shown in c and d , respectively. ( e and f ) CORO1C vector attenuates miR-206-mediated inhibitory effect on the vertical migration and invasion of A549 cells. A549 cells were transfected with NC vector or CORO1C vector, and then subjected to transwell migration and transwell invasion assays. Representative images (100 × magnification) and the quantitative data are shown in e and f , representatively. g CORO1C vector rescues miR-206-induced inhibitory effect of EMT markers. The cells were transfected with CORO1C vector or NC vector. After 24 h the cells were collected and subjected to western blotting assay. Quantitative data are presented as mean ± SEM. *P < 0.05 and * **P < 0.001 compared with the NC vector group, # P < 0.05 and ## P < 0.01 compared with the NC vector+ NC mimic group

    Article Snippet: Antibodies against vimentin (D21H3), E-cadherin (24E10), N-cadherin (D4R1H), ZO-1(D6L1E) and Snail (C15D3), CORO1C (D6K5B) and β-actin (13E5) were purchased from Cell Signaling Technology (Danvers, MA).

    Techniques: Over Expression, Plasmid Preparation, Transfection, Expressing, Reverse Transcription Polymerase Chain Reaction, Inhibition, MTT Assay, Migration, Wound Healing Assay, Western Blot